Louie Anderson, whose more than four-decade career as a comedian and actor included his unlikely, Emmy-winning performance as mom to twin adult sons in the TV series 鈥淏askets,鈥� died Friday. He was 68.

Anderson died at a hospital in Las Vegas of complications from cancer, said Glenn Schwartz, his longtime publicist. Anderson had a a type of non-Hodgkin lymphoma, Schwartz said previously.

Anderson won a 2016 Emmy for best supporting actor for his portrayal of Christine Baskets, mother to twins played by Zach Galifianakis. Anderson received three consecutive Emmy nods for his performance.

He was a familiar face elsewhere on TV, including as host of a revival of the game show 鈥淔amily Feud鈥� from 1999 to 2002, and on comedy specials and in frequent late-night talk show appearances.

Anderson voiced an animated version of himself as a kid in 鈥淟ife With Louie.鈥� He created the cartoon series, which first aired in prime time in late 1994 before moving to Saturday morning for its 1995-98 run. Anderson won two Daytime Emmy Awards for the role.

He made guest appearances in several TV series, including 鈥淪crubs鈥� and 鈥淭ouched by an Angel,鈥� and was on the big screen in 1988鈥瞫 鈥淐oming to America鈥� and in last year鈥檚 sequel to the Eddie Murphy comedy.

Anderson also toured regularly with his stand-up act and as a stand-up comedian.

鈥擫ynn Elber, The Associated Press